Prothrombotic States in Portal Vein Thrombosis and Budd-Chiari Syndrome in India: A Systematic Review and Meta-Analysis

نویسندگان

چکیده

Background and Aim: Both Budd-Chiari syndrome (BCS) portal vein thrombosis (PVT) have been linked to various prothrombotic (PT) conditions. The PT profile in Asians is different from the West there are no nationwide epidemiological surveys India. Hence, present meta-analysis was aimed at analyzing prevalence of acquired hereditary thrombophilia among Indian patients with non-cirrhotic PVT BCS. Methods: A comprehensive literature search Embase, Medline, Scopus conducted January 2000 Feb 2022 for studies evaluating conditions Pooled rates across were expressed summative statistics. Results: Thirty-five 1005 1391 BCS included meta-analysis. At least one condition seen 46.2% (28.7 -63.7) 44.9% (37.3 - 60.7) patients. Multiple 13.0% (4.2 -21.8) 7.9% (3.5-12.4) Among patients, hyperhomocysteinemia commonest (21.6%) followed by Protein C (PC) deficiency (10.7%), JAK-2 mutation (8.5%), antiphospholipid antibodies (APLA) (7.5%). BCS, PC (10.6%) MTHFR (9.8%), APLA (9.7%), (9.1%). Prothrombin gene not less than 1% cases PVT. Conclusion: abdominal that Western data a lower

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ژورنال

عنوان ژورنال: Journal of clinical and experimental hepatology

سال: 2023

ISSN: ['0973-6883', '2213-3453']

DOI: https://doi.org/10.1016/j.jceh.2023.07.125